AI Bench to BedsideAI2B · Verjans Liao Lab
Australian Institute for Machine Learning
College of Health · College of Engineering and IT
Adelaide University

Project · 2020–2025 · Trial complete

RAPIDx AI: AI for chest pain in the emergency department

The first AI-based randomised clinical trial for chest pain. Machine-learning decision support was embedded in emergency-department workflow across 12 South Australian hospitals, and about 14,000 patients were enrolled.

At a glance

Status
Trial complete
Setting
12 SA Health hospitals, emergency departments
Patients
About 14,000
Funding
NHMRC partnership project, $1.23M, led by Flinders University
Our role
The AI was built by the group. Zhibin Liao was AI lead for the NHMRC partnership project (2021–2023); Johan Verjans is AI lead for RAPIDx AI.

Why it matters

Chest pain is one of the most common reasons people come to an emergency department, and deciding quickly who is having a heart attack is hard. RAPIDx AI tested whether machine-learning support for that decision could be built into real emergency-department workflow and evaluated as a randomised trial.

It also established the clinical-governance and integration pathway that the lab's later systems, AUScribe and AutoMedic, are built on. Results were presented at ESC Congress 2024 (ESC press release).

Related papers

Re-engineering the Clinical Approach to Suspected Cardiac Chest Pain Assessment in the Emergency Department by Expediting Research Evidence to Practice Using Artificial Intelligence (RAPIDx AI): a Cluster Randomized Study Design Khan E, Lambrakis K, Briffa T, Cullen LA, Karnon J, Papendick C, Quinn S, Tideman P, van den Hengel A, Verjans J, Chew DP American Heart Journal 285 2025 · 10 citations
Prognostic Implications of Machine Learning Algorithm-Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction Lambrakis K, Khan E, Liao Z, Gerlach J, Nelson AJ, Goodman SG, Briffa T, Cullen L, Verjans J, Chew D Heart, Lung and Circulation 34(5) 2025
Machine-Learning for Phenotyping and Prognostication of Myocardial Infarction and Injury in Suspected Acute Coronary Syndrome Khan E, Lambrakis K, Liao Z, Gerlach J, Briffa T, Cullen L, Nelson AJ, Verjans J, Chew DP JACC: Advances 3(9) 2024 · 15 citations

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